NICOTINAMIDE MONONUCLEOTIDE-NMN Capsule

• CAS No.: 1094-61-7
• Formula: C11H15N2O8P
• Environmental Protection: Yes
• Color: White
• Classification: NMN
• Function: Keeping Health and Promoting Growth
• Model NO.: NMN Capsule
• Appearance: Capsule
• Delivery time: 10-25 days
• Transport Package: 60 Capsules / Bottle
• Specification: 500mg
• Trademark: EIBOR
• Origin: Shanghai
• HS Code: 2934999001
• Production Capacity: 1000kgs/ Month

Product Description

WHAT IS NMN?

NMN is an entirely natural compound found in our bodies. Various food sources also contain this compound in minuscule amounts. Edamame which has one of the higher contents, only show less than 1.9mg/100g. NMN is a direct and potent NAD+ supplement. Mice given an oral supplement of NMN showed increased liver NAD+ levels in just 10 minutes and showed an increase in muscle tissue by 30 minutes. Increased NAD+ levels stimulate energy DNA repair and SIRTUIN activity. SIRTUINS are the longevity-genes shown to be active during caloric restriction and life-extension in many animal models.

 

• NAD+ helps to breakdown food like sugars into energy.
• Promotes Healthy Cardiovascular Function.
• DNA Repair - NAD+ is used to repair broken DNA strands.
• SIRTUIN Activator - NAD+ is required for our longevity genes to work.
• NMN is THE compound used by Harvard Scientists to reverse some signs of aging tissue in mice that started the rush to NAD supplements.

 

THE SCIENCE

Scientists have now confirmed a direct link between falling NAD+ levels and aging in both animals and human subjects. A breakthrough study published by Harvard scientists in 2013 showed for the first time that some aspects of aging might be reversible. After treating old mice with NMN, several biometric markers that were subsequently measured resembled those of young mice: "the human equivalent of a 60-year old with markers resembling that of a 20-year old". The research and understanding into NAD+ metabolomics are ongoing, but what the science has highlighted thus far, is the importance of supporting and maintaining our NAD+ levels.A long-term evaluation of oral supplementation of NMN in mice was found to be effective at improving NAD+ levels safely. Mice supplemented with NMN vs. a control group showed notable age-associated differences in mass, energy, blood sugar, lipid, gene expression changes, mitochondrial oxygen use, eye function, bone density and immune function with no apparent toxic effects. This product is not intended to diagnose, treat, cure or prevent and diseases.

Is there a correlation between falling NAD levels and aging?

Scientists have discovered that as we get older, our NAD+ levels steadily decrease, and by the time we get to our late 70s &80s, our NAD+ levels appear to be much lower, than those of younger people. The science is starting to clearly show a definite correlation between falling NAD levels and an age-related decline in health & wellness. In 2013 Harvard researchers published a study, where they were able to reverse some parts of aging by treating old mice with NMN, a direct NAD+ precursor supplement. After ten days of treatment, key biometrics markers measured resembled those of much younger mice. For the first time, we have real evidence that some aspects of aging may be reversible. In 2017 the same team published a follow-up article. It demonstrated a new understanding of how NAD+ is not only used to repair damaged DNA but how it also stimulates the repair process. It does this by blocking another protein called DBC1 that interferes with the PARP-1 DNA Repair enzyme.

New NMN Transporter Slc12a8 Found

How NMN is taken up into cells has not been entirely clear. However, a recent study has identified that Slc12a8 is highly expressed and regulated by NAD+ in the small intestine. When NAD+ levels are low, the cells respond by turning on more Slc12a8 transporters. It has been further shown that Slc12a8 specifically transports NMN and not NR. The study demonstrates that Slc12a8 has a critical role in regulating intestinal and systemic NAD+ supply.