| Customization: | Available |
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| CAS No.: | 1094-61-7 |
| Formula: | C11H15N2O8P |
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WHAT IS NMN?
NMN is an entirely natural compound found in our bodies. Various food sources also contain this compound in minuscule amounts. Edamame which has one of the higher contents, only show less than 1.9mg/100g. NMN is a direct and potent NAD+ supplement. Mice given an oral supplement of NMN showed increased liver NAD+ levels in just 10 minutes and showed an increase in muscle tissue by 30 minutes. Increased NAD+ levels stimulate energy DNA repair and SIRTUIN activity. SIRTUINS are the longevity-genes shown to be active during caloric restriction and life-extension in many animal models.
THE SCIENCE
Scientists have now confirmed a direct link between falling NAD+ levels and aging in both animals and human subjects. A breakthrough study published by Harvard scientists in 2013 showed for the first time that some aspects of aging might be reversible. After treating old mice with NMN, several biometric markers that were subsequently measured resembled those of young mice: "the human equivalent of a 60-year old with markers resembling that of a 20-year old". The research and understanding into NAD+ metabolomics are ongoing, but what the science has highlighted thus far, is the importance of supporting and maintaining our NAD+ levels.A long-term evaluation of oral supplementation of NMN in mice was found to be effective at improving NAD+ levels safely. Mice supplemented with NMN vs. a control group showed notable age-associated differences in mass, energy, blood sugar, lipid, gene expression changes, mitochondrial oxygen use, eye function, bone density and immune function with no apparent toxic effects. This product is not intended to diagnose, treat, cure or prevent and diseases.
Scientists have discovered that as we get older, our NAD+ levels steadily decrease, and by the time we get to our late 70s &80s, our NAD+ levels appear to be much lower, than those of younger people. The science is starting to clearly show a definite correlation between falling NAD levels and an age-related decline in health & wellness. In 2013 Harvard researchers published a study, where they were able to reverse some parts of aging by treating old mice with NMN, a direct NAD+ precursor supplement. After ten days of treatment, key biometrics markers measured resembled those of much younger mice. For the first time, we have real evidence that some aspects of aging may be reversible. In 2017 the same team published a follow-up article. It demonstrated a new understanding of how NAD+ is not only used to repair damaged DNA but how it also stimulates the repair process. It does this by blocking another protein called DBC1 that interferes with the PARP-1 DNA Repair enzyme.
How NMN is taken up into cells has not been entirely clear. However, a recent study has identified that Slc12a8 is highly expressed and regulated by NAD+ in the small intestine. When NAD+ levels are low, the cells respond by turning on more Slc12a8 transporters. It has been further shown that Slc12a8 specifically transports NMN and not NR. The study demonstrates that Slc12a8 has a critical role in regulating intestinal and systemic NAD+ supply.
| Why do you choose us? Our advantages are below: |
| 1. We have more than 12 years professional experience on medical products since 2005. We are Gold Member and SGS Audited supplier on www.made-in-china.com since 2005. |
| 2. Our company is certified TUV CE 0197 and ISO 13485, Free Sales Certificate, FDA. Our products are compliant with all major quality certifications and higher quality level than clients' expectations. |
| 3. We are reliable partner to our clients, we keep good and long term mutual cooperation with our clients, we grow with our clients together to expand market. |
| 4. Our factory locaiton is very convenient for air and ocean shipping. We are one hour driving to Shanghai PuDong International Airport, and one hour driving to Shanghai International Ocean seaport. It's also convenient for foreign clients to visit our company. |
| 5. More advantages are waiting for you to discover |
China HuaMei Medical Instrument Co., Ltd. is located in Shanghai, our company is the leading force in the industry.
China HuaMei Medical Instrument Co Ltd is supplying various surgical instruments, both reusable and sterile disposable quality instruments. HuaMei Medical is certified CE and ISO 13485:2016.
HuaMei Medical is supplying medical packaging and sterilization services, including ETO sterilization and Gamma radiation. HuaMei Medical built its own medical packing clean room which reaches to ISO 8, Grade 100, 000. It ensures us that HuaMei Medical can pack all valuable surgical instruments in international standard medical clean room.
You will have full confidence and satisfaction in sending your bulk orders to HuaMei Medical. Every container of goods are inspected thoroughly and strictly according to HuaMei Medical QC management policy, all the goods have to be approved by QC team before shipping. All customers repeat orders every year and HuaMei Medical turnover is increasing accordingly. The reasons are simple - because HuaMei Medical care the quality, delivery time and cost for customers.
You are welcome to visit our factory in Shanghai, we look forward to establish mutual cooperation with you.
Please feel free to send us your inquiry now. Contact Mr Peter Jiao.
FAQ
| Q1. Do you accept OEM or ODM? |
| Yes. We can accept OEM orders, we are supplying OEM products for some worldwide famous companies. You are more welcome to choose our ODM products. |
| Q2. How can i get accurate quotation from your company efficiently? |
| If you can advise your detailed product specification, order volume, quality requirements, packing requirements, products pictures, destination seaport, we can offer you accurate CNF quotation shortly. |
| Q3. What's your payment term? |
| T/T( telegraphic transfer) , 40% deposit with order, 60% balance against Bill of Lading copy. L/C at sight. Western Union ,the other methods also can be discussed. |
| Q4. Can you make samples for approve quality before place bulk orders with your company? |
| Yes we can make customized samples for you approve quality. There are several clients asking for samples every day, we can not offer free samples to every one, we need to charge 100usd for courier cost and sample fee, after you place orders with our company, we can deduct 100usd from Proforma Invoice for you. You can use Paypal, Western Union, Alipay and Wechat to transfer 100usd to us. |
| Q5. Can you arrange shipment for us? |
| We have excellent forwarder partners who are specialized in air freight, sea freight, and express courier. We can offer you CNF, FOB, even our forwarder can send the shipment to your warehouse directly upon your request. |
Why choose us for long term cooperation?
1. Fast reply and reaction. Our professional salesmen will reply your inquiry within 24 hours between Monday and Friday.
3. Reasonable pricing based on high quality products. We always offer high quality products with competitive prices to our clients.
4.Our products passed international standard test, like SGS.
5.Product diversity. We have variety of different products supplying to you.
6. Convenient location. Our company is located in Shanghai, close to Shanghai international airport and seaport. You are welcome to visit our factory anytime conveniently
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